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12 January 2008

Sample Medical Translation

English Source Text
To identify factors that influence the clinical response to 5-fluorouracil (5-FU), we studied the correlation between in vitro sensitivity to 5-FU and the expression of seven biological markers. The markers, thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), pyrimidine nucleoside phosphorylase, p53 (wild/mutant), p21, cyclo-oxygenase-2, and inducible nitric oxide synthase were measured in tumour tissues from 32 colorectalcancer patients. The activities of TS and DPD were significantly lower in the tumours sensitive to 5-FU compared with those that were not sensitive to 5-FU. In tumours with TS <>

Untuk mengidentifikasi faktor-faktor yang mempengaruhi respons klinis terhadap 5-florourasil (5-FU), kami meneliti korelasi antara sensitifitas in vitro terhadap 5-FU dan kadar tujuh indikator biologis. Indikator tersebut, yaitu timidilat sintasa (TS), dihidropirimidin dehidrogenasa (DPD), pirimidin nukleosida fosforilasa, p53 (liar/mutan), p21, siklo-oksigenasa-2, dan sintasa oksida nitrat induktif diukur pada jaringan tumor dari 32 pasien penderita kanker kolorektum. Aktifitas TS dan DPD jauh lebih rendah pada tumor yang peka terhadap 5-FU dibandingkan dengan tumor yang tidak peka terhadap 5-FU. Pada tumor dengan TS <>

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